Cancer Genetics and Epigenetics: Two Sides of the Same Coin and Comprehensive High-Throughput Arrays for Relative Methylation – Article Example
First Last Number Summary DISCUSSION The two selected articles of genetics are vital for having an in-depth knowledge in the field of genetics. In this regard, the article of You and Jones (9) attempts to reveal that the genetics behind the carcinogenic cells and the concept of epigenetic is the same. Respectively, the authors commented that genetic alteration and epigenetic has been considered as two different mechanisms contributing to carcinogenesis. However, their recent study revealed that these two genetic factors in the field of carcinogenesis are the same.
The article of Irizarry, Ladd-Acosta, Carvalho, Wu, Brandenburg, Jeddeloh, Wen and Feinberg (780) suggested that their research objective of discovering the effective tool to identify the genomic locations has been a major success in the field of genetic alteration and epigenetic. This new tool shows nearly ‘100% sensitivity at 90% specificity with McrBC’. In addition, the new tool is termed as ‘Comprehensive high-throughput arrays for relative Methylation’ (CHARM).
The study of You and Jones (9) in the field of carcinogenesis and genetics revealed that cancer genetics and epigenetic are the same. The authors further conclude that genetic alteration, which is not inherent to the next generation, is the major factor that leads to the formation of carcinogenic cells or cancer. Similar cause is also notable from the epigenetic process that leads to mutation of the cells and finally causes cancer.
In the experimental study of Ladd-Acosta, Carvalho, Wu, Brandenburg, Jeddeloh, Wen and Feinberg (780), a major conclusion has been drawn with regard to the effectiveness of CHARM. CHARM is highly effective in determining the genomic locations. The effectiveness of the tool is evident from the high sensitivity and specificity in identifying the locations of the genomes. Moreover, the researchers concluded that CHARM is relatively inexpensive tool and is highly effective in determine genome width. Furthermore, the researchers determined that individual sample analysis could be executed with the assistance of this tool, wherein the sample has high density.
EVIDENCES FOR CONCLIUSIONS
There are certain research evidences based upon which You and Jones (9) concluded their findings. In this context, the authors proposed that in their research study, exomes have undergone mutations in the DNA structure. This has been discovered as a major factor that contributed to the cause of cancer. Moreover, it is evident from the research observations that these mutations in exomes has led to the damage of methyl bonding in DNA molecules. Furthermore, it is evident that these mutations have led to the modifications in the histone proteins and nucleosome positioning. This, subsequently lead to the alteration of gene expression that ultimately causes cancer.
The conclusion made by Ladd-Acosta, Carvalho, Wu, Brandenburg, Jeddeloh, Wen and Feinberg (780) have certain experimental evidences. Based on the experimental output and evidences, the reliability of the conclusive outcome increased. In this regard, the experiment process that comprises statistical analysis and tiling arrays in the array design strategy has improved the effectiveness in determining the neighborhood genomic locations. This strategy has improved the level of information that can be derived and attained from the study. Furthermore, the effectiveness of CHARM is highly evident from the improved specificity and sensitivity in identifying the genomic locations. The researchers suggested that nearly 100% sensitivity of the genomic locations would be achieved at 90% specificity with McrBC.
The scientific discovery in the research study of You and Jones (9) implied a greater opportunity to ascertain new therapies or treatment to cancer. The discovery of the similar identities of cancer genetics and epigenetic would support other researchers to unfold several other concepts related to cancer genetics. This also signifies of an opportunity to the researchers to discover the method through which the damage and the rapid mutations of DNA molecules can be controlled. This would eventually lead to the control in the production of carcinogenic cells in human body and simultaneous repair the damaged cells. Additionally, the researches made in this field have been an important discovery for curing cancer.
The experimental discovery of Irizarry, Ladd-Acosta, Carvalho, Wu, Brandenburg, Jeddeloh, Wen and Feinberg (780) with regard to the effectiveness CHARM assists in identifying genomic locations. This significantly implies that CHARM would be highly important to other researchers in their field of genetics study. Moreover, it implies that technology would lead to the discovery of several other facts in genetic engineering studies. In this context, high specificity and sensitivity of CHARM implies considerable advantage to the study of human diseases. This would also lead to the determination of the root cause of several human diseases. Additionally, the study and experiments made in this field have made an important contribution towards understanding cancer genetics and epigenetics.
Irizarry, Rafael A., Christine Ladd-Acosta, Benilton Carvalho, Hao Wu, Sheri A. Brandenburg, Jeffrey A. Jeddeloh, Bo Wen and Andrew P. Feinberg. “Comprehensive high-throughput arrays for relative Methylation (CHARM).” Genome Research, 18 (2008): 780-790. Print.
You, Jeung Soo and Peter A. Jones. “Cancer Genetics and Epigenetics: Two Sides of the Same Coin?” NIH Public Access, 22 (2012): 9-20.